{"metadata":{"accession":"PF08903","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR048496","hierarchy":null,"name":{"name":"Domain of unknown function DUF1846, N-terminal","short":"DUF1846"},"description":[{"text":"<p>This domain is found in a family of proteins that are functionally uncharacterised, known as UPF0371. Some members of the family are annotated as ATP-dependent peptidases. This is a P-loop-like domain (pdbe:3BH1).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0023","name":"P-loop_NTPase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":1347,"pathways":0,"proteins":1347,"proteomes":1315,"sets":1,"structural_models":{"alphafold":915},"structures":2,"taxa":2136},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":44,"alignment:full":880},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}