This family of proteins are functionally uncharacterised. The C-terminus contains a cluster of cysteines that are similar to the iron-sulfur cluster found at the N-terminus of [pfam:PF04055].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00044953":{"PMID":16352836,"ISBN":null,"volume":"188","issue":"1","year":2006,"title":"Reconstruction and regulation of the central catabolic pathway in the thermophilic propionate-oxidizing syntroph Pelotomaculum thermopropionicum.","URL":null,"raw_pages":"202-10","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Kosaka T","Uchiyama T","Ishii S","Enoki M","Imachi H","Kamagata Y","Ohashi A","Harada H","Ikenaga H","Watanabe K."],"DOI_URL":"http://dx.doi.org/10.1128/JB.188.1.202-210.2006"}},"set_info":{"accession":"CL0036","name":"TIM_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":8,"interactions":0,"matches":987,"pathways":0,"proteins":984,"proteomes":893,"sets":1,"structural_models":{"alphafold":709},"structures":0,"taxa":1967},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":68,"alignment:full":685},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}