This protein family appears to be primarily involved in transcriptional regulation and cellular processes. Members of this family, such as the one represented by [swissprot:Q8E4L3] (gene gbs1388), exhibit high levels of transcriptional activity and may be regulated by factors like the rex gene, indicating a role in significant cellular processes [[cite:PUB00156067]]. Another member, [swissprot:A6M310], gene name cbei_4884), is implicated in strain degeneration and regulatory functions linked to sporulation and solvent formation in Clostridium beijerinckii, suggesting conservation among clostridial species [[cite:PUB00156068]]. The sgo_1308 gene encodes a protein [swissprot:A8AXS9] containing the DUF1836 domain which belongs to the helix-turn-helix (HTH) clan, hinting at its role in transcriptional regulation, specifically influencing bacterial hemolysin III [[cite:PUB00156066]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00156066":{"PMID":25855127,"ISBN":null,"volume":"97","issue":"2","year":2015,"title":"Critical roles of arginine in growth and biofilm development by Streptococcus gordonii.","URL":null,"raw_pages":"281-300","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Jakubovics NS","Robinson JC","Samarian DS","Kolderman E","Yassin SA","Bettampadi D","Bashton M","Rickard AH."],"DOI_URL":"https://doi.org/10.1111/mmi.13023"},"PUB00156068":{"PMID":36704551,"ISBN":null,"volume":"13","issue":null,"year":2022,"title":"Clostridium beijerinckii strain degeneration is driven by the loss of Spo0A activity.","URL":null,"raw_pages":"1075609","medline_journal":"Front Microbiol","ISO_journal":"Front Microbiol","authors":["Humphreys JR","Debebe BJ","Diggle SP","Winzer K."],"DOI_URL":"https://doi.org/10.3389/fmicb.2022.1075609"},"PUB00156067":{"PMID":34370789,"ISBN":null,"volume":"17","issue":"8","year":2021,"title":"NAD+ pool depletion as a signal for the Rex regulon involved in Streptococcus agalactiae virulence.","URL":null,"raw_pages":"e1009791","medline_journal":"PLoS Pathog","ISO_journal":"PLoS Pathog","authors":["Franza T","Rogstam A","Thiyagarajan S","Sullivan MJ","Derre-Bobillot A","Bauer MC","Goh KGK","Da Cunha V","Glaser P","Logan DT","Ulett GC","von Wachenfeldt C","Gaudu P."],"DOI_URL":"https://doi.org/10.1371/journal.ppat.1009791"}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":2156,"pathways":0,"proteins":2153,"proteomes":1785,"sets":1,"structural_models":{"alphafold":1398},"structures":0,"taxa":2610},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":26,"alignment:full":1208},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}