This family of proteins are functionally uncharacterised and are predicted to adopt an all-beta fold [[cite:PUB00034476]]. They are often found in gene neighborhoods containing genes for an NlpC peptidase and a Ubiquitin domain predicted to be involved in tail assembly [[cite:PUB00034476]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00034476":{"PMID":16859499,"ISBN":null,"volume":"7","issue":"7","year":2006,"title":"The prokaryotic antecedents of the ubiquitin-signaling system and the early evolution of ubiquitin-like beta-grasp domains.","URL":null,"raw_pages":"R60","medline_journal":"Genome Biol","ISO_journal":"Genome Biol.","authors":["Iyer LM","Burroughs AM","Aravind L."],"DOI_URL":"http://dx.doi.org/10.1186/gb-2006-7-7-r60"}},"set_info":{"accession":"CL0249","name":"Phage_tail_L"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":524,"pathways":0,"proteins":524,"proteomes":456,"sets":1,"structural_models":{"alphafold":242},"structures":0,"taxa":993},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":308},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}