Solution of the structure of the Lactobacillus plantarum protein from this family has indicated a potential new fold with remote similarities to TBP-like (TATA-binding protein) structures. This similarity, in combination with genomic context analysis, leads us to propose an involvement in amino-acid metabolism. The potentially novel fold is an alpha + beta fold comprising two beta sheets packed against a single helix. The enzyme is present in the cytosol.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00055862":{"PMID":20944212,"ISBN":null,"volume":"66","issue":"Pt 10","year":2010,"title":"Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism.","URL":null,"raw_pages":"1205-10","medline_journal":"Acta Crystallogr Sect F Struct Biol Cryst Commun","ISO_journal":"Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.","authors":["Bakolitsa C","Kumar A","Carlton D","Miller MD","Krishna SS","Abdubek P","Astakhova T","Axelrod HL","Chiu HJ","Clayton T","Deller MC","Duan L","Elsliger MA","Feuerhelm J","Grzechnik SK","Grant JC","Han GW","Jaroszewski L","Jin KK","Klock HE","Knuth MW","Kozbial P","Marciano D","McMullan D","Morse AT","Nigoghossian E","Okach L","Oommachen S","Paulsen J","Reyes R","Rife CL","Tien HJ","Trout CV","van den Bedem H","Weekes D","Xu Q","Hodgson KO","Wooley J","Deacon AM","Godzik A","Lesley SA","Wilson IA."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":699,"pathways":0,"proteins":699,"proteomes":699,"sets":0,"structural_models":{"alphafold":483},"structures":1,"taxa":999},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":23,"alignment:full":281},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2iay","name":"Crystal structure of a duf1831 family protein (lp2179) from lactobacillus plantarum at 1.20 A resolution"}}}