{"metadata":{"accession":"PF08864","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR014963","hierarchy":null,"name":{"name":"ReoY-like, N-terminal domain","short":"ReoY_N"},"description":[{"text":"<p>This entry represents the N-terminal domain of Peptidoglycan synthesis regulatory protein ReoY ([swissprot:Q8Y5Y2]) which is involved in the PASTA kinase-mediated signalling pathway regulating peptidoglycan synthesis to maintain cell wall integrity [[cite:PUB00104135]]. It modulates peptidoglycan (PG) synthesis pathway committed-step enzyme MurA [[cite:PUB00104135]]. ReoY positively modulates ClpCP-dependent proteolysis of MurA, thereby regulating PG synthesis and inhibiting intrinsic cephalosporin resistance [[cite:PUB00104135]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00104135":{"PMID":32469310,"ISBN":null,"volume":"9","issue":null,"year":2020,"title":"PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM. ","URL":null,"raw_pages":"e56048","medline_journal":"Elife","ISO_journal":"Elife","authors":["Wamp S","Rutter ZJ","Rismondo J","Jennings CE","Moller L","Lewis RJ","Halbedel S."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":1238,"pathways":0,"proteins":1238,"proteomes":1139,"sets":0,"structural_models":{"alphafold":807},"structures":1,"taxa":1562},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":25,"alignment:full":551},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}