{"metadata":{"accession":"PF08838","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR014938","hierarchy":null,"name":{"name":"Protein of unknown function (DUF1811)","short":"DUF1811"},"description":[{"text":"<p>This family includes uncharacterised proteins predominantly found in Firmicutes, including Uncharacterized protein YfhH from Bacillus subtilis and protein GK0453 from Geobacillus kaustophilus. GK0453 shows two small domains: an helix-turn-helix like motif is found in its N-terminal domain while an SH3-like beta-barrel like structure is observed its C-terminal region. Its specific function is unknown [[cite:PUB00100670]]. Some of the members of this protein family are annotated as transcriptional regulators (see Q3EXU7, Q81I96).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00100670":{"PMID":23545635,"ISBN":null,"volume":"69","issue":"Pt 4","year":2013,"title":"Structure of the hypothetical DUF1811-family protein GK0453 from Geobacillus kaustophilus HTA426.","URL":null,"raw_pages":"342-5","medline_journal":"Acta Crystallogr Sect F Struct Biol Cryst Commun","ISO_journal":"Acta Crystallogr Sect F Struct Biol Cryst Commun","authors":["Padmanabhan B","Nakamura Y","Antonyuk SV","Strange RW","Hasnain SS","Yokoyama S","Bessho Y."],"DOI_URL":null}},"set_info":{"accession":"CL0010","name":"SH3"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":993,"pathways":0,"proteins":993,"proteomes":990,"sets":1,"structural_models":{"alphafold":620},"structures":2,"taxa":1249},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":19,"alignment:full":439},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1sf9","name":"Crystal Structure of Bacillus subtilis YfhH Protein : Putative Transcriptional Regulator"}}}