{"metadata":{"accession":"PF08768","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR014878","hierarchy":null,"name":{"name":"THAP4-like, heme-binding beta-barrel domain","short":"THAP4_heme-bd"},"description":[{"text":"<p>This domain can be found in THAP4 from mammals and At1g79260 from Arabidopsis. THAP4 catalyzes the heme-based conversion of peroxynitrite into nitrate-NO3- in vitro [[cite:PUB00095798]]. At1g79260 is a nitrophorin-like heme-binding protein that may reversibly bind nitric oxide (NO) and be involved in NO transport [[cite:PUB00063678]]. This entry also includes the beta-barrel domain of Caenorhabditis elegans protein male abnormal 7 (Mab-7) which plays an important role in determining body shape and sensory ray morphology [[cite:PUB00095799]]. Nitrobindins (Nbs), constituting a heme-protein family spanning from bacteria to Homo sapiens, display an all-beta-barrel structural organisation. Proteins containing this domain are putatively related to fatty acid-binding proteins (FABPs) [[cite:PUB00040845]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00095799":{"PMID":17959165,"ISBN":null,"volume":"312","issue":"1","year":2007,"title":"mab-7 encodes a novel transmembrane protein that orchestrates sensory ray morphogenesis in C. elegans.","URL":null,"raw_pages":"353-66","medline_journal":"Dev Biol","ISO_journal":"Dev Biol","authors":["Tsang SW","Nguyen CQ","Hall DH","Chow KL."],"DOI_URL":null},"PUB00040845":{"PMID":17172346,"ISBN":null,"volume":"189","issue":"5","year":2007,"title":"The crystal structure of Rv0813c from Mycobacterium tuberculosis reveals a new family of fatty acid-binding protein-like proteins in bacteria.","URL":null,"raw_pages":"1899-904","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Shepard W","Haouz A","Grana M","Buschiazzo A","Betton JM","Cole ST","Alzari PM."],"DOI_URL":"http://dx.doi.org/10.1128/JB.01435-06"},"PUB00095798":{"PMID":30524950,"ISBN":null,"volume":"8","issue":"12","year":2018,"title":"Human nitrobindin: the first example of an all-β-barrel ferric heme-protein that catalyzes peroxynitrite detoxification.","URL":null,"raw_pages":"2002-2010","medline_journal":"FEBS Open Bio","ISO_journal":"FEBS Open Bio","authors":["De Simone G","di Masi A","Polticelli F","Ascenzi P."],"DOI_URL":null},"PUB00063678":{"PMID":19938152,"ISBN":null,"volume":"78","issue":"4","year":2010,"title":"The structure and NO binding properties of the nitrophorin-like heme-binding protein from Arabidopsis thaliana gene locus At1g79260.1.","URL":null,"raw_pages":"917-31","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Bianchetti CM","Blouin GC","Bitto E","Olson JS","Phillips GN Jr."],"DOI_URL":"http://dx.doi.org/10.1002/prot.22617"}},"set_info":{"accession":"CL0116","name":"Calycin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":73,"interactions":0,"matches":7560,"pathways":0,"proteins":7499,"proteomes":5589,"sets":1,"structural_models":{"alphafold":5205},"structures":16,"taxa":9588},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":126,"alignment:full":4461},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3ia8","name":"The structure of the C-terminal heme nitrobindin domain of THAP domain-containing protein 4 from Homo sapiens"}}}