{"metadata":{"accession":"PF08735","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR014846","hierarchy":null,"name":{"name":"Putative pyruvate format-lyase activating enzyme (DUF1786)","short":"DUF1786"},"description":[{"text":"<p>This family is annotated as pyruvate formate-lyase activating enzyme ([ec:1.97.1.4]) in UniProt. It is not clear where this annotation comes from.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00044952":{"PMID":15581584,"ISBN":null,"volume":"433","issue":"1","year":2005,"title":"Pyruvate formate-lyase activating enzyme: elucidation of a novel mechanism for glycyl radical formation.","URL":null,"raw_pages":"288-96","medline_journal":"Arch Biochem Biophys","ISO_journal":"Arch. Biochem. Biophys.","authors":["Buis JM","Broderick JB."],"DOI_URL":"http://dx.doi.org/10.1016/j.abb.2004.09.028"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":241,"pathways":0,"proteins":240,"proteomes":236,"sets":0,"structural_models":{"alphafold":207},"structures":0,"taxa":528},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":33,"alignment:full":148},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}