{"metadata":{"accession":"PF08699","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR014811","hierarchy":null,"name":{"name":"Argonaute linker 1 domain","short":"ArgoL1"},"description":[{"text":"<p>ArgoL1 is a region found in argonaute [[cite:PUB00035384]] proteins. It normally co-occurs with [pfam:PF02179] and [pfam:PF02171]. It is a linker region between the N-terminal and the PAZ domains. It contains an alpha-helix packed against a three-stranded antiparallel beta-sheet with two long beta-strands (beta8 and beta9) of the sheet spanning one face of the adjacent N and PAZ domains. L1 together with linker 2, L2, PAZ and ArgoN forms a compact global fold [[cite:PUB00038652]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00038652":{"PMID":16061186,"ISBN":null,"volume":"19","issue":"3","year":2005,"title":"Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavage.","URL":null,"raw_pages":"405-19","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Yuan YR","Pei Y","Ma JB","Kuryavyi V","Zhadina M","Meister G","Chen HY","Dauter Z","Tuschl T","Patel DJ."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2005.07.011"},"PUB00035384":{"PMID":16216572,"ISBN":null,"volume":"13","issue":"10","year":2005,"title":"Structure and function of argonaute proteins.","URL":null,"raw_pages":"1403-8","medline_journal":"Structure","ISO_journal":"Structure","authors":["Hall TM."],"DOI_URL":"http://dx.doi.org/10.1016/j.str.2005.08.005"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":419,"interactions":0,"matches":21522,"pathways":0,"proteins":21447,"proteomes":3107,"sets":0,"structural_models":{"alphafold":18036},"structures":74,"taxa":8566},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":215,"alignment:full":16069},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}