{"metadata":{"accession":"PF08683","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR014797","hierarchy":null,"name":{"name":"Microtubule-binding calmodulin-regulated spectrin-associated","short":"CAMSAP_CKK"},"description":[{"text":"<p>This is the C-terminal domain of a family of eumetazoan proteins collectively defined as calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal, or CKK, domain - defined as being present in CAMSAP, KIAA1078 and KIAA1543, The C-terminal domain is the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition of neurite extension, probably by blocking microtubule function. CKK represents a domain that has evolved with the metazoa. The structure of a murine hypothetical protein from RIKEN cDNA has shown the domain to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Calmodulin-regulated_spectrin-associated_CKK_domain","extract":"<p>In molecular biology, the <b>calmodulin-regulated spectrin-associated CKK domain</b> is a domain which occurs at the C-terminus of a family of eumetazoan proteins collectively defined as calmodulin-regulated spectrin-associated, or CAMSAP, proteins. CAMSAP proteins carry an N-terminal region that includes the CH domain, a central region including a predicted coiled-coil and this C-terminal. This domain is the part of the CAMSAP proteins that binds to microtubules. The domain appears to act by producing inhibition of neurite extension, probably by blocking microtubule function. CKK represents a domain that has evolved with the metazoa. The structure of this domain in murine hypothetical protein has shown the domain to adopt a mainly beta barrel structure with an associated alpha-helical hairpin.</p>","thumbnail":null}],"literature":{"PUB00055957":{"PMID":19508979,"ISBN":null,"volume":"26","issue":"9","year":2009,"title":"The CKK domain (DUF1781) binds microtubules and defines the CAMSAP/ssp4 family of animal proteins.","URL":null,"raw_pages":"2005-14","medline_journal":"Mol Biol Evol","ISO_journal":"Mol. Biol. Evol.","authors":["Baines AJ","Bignone PA","King MD","Maggs AM","Bennett PM","Pinder JC","Phillips GW."],"DOI_URL":"http://dx.doi.org/10.1093/molbev/msp115"}},"set_info":{"accession":"CL0350","name":"PRC-barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":57,"interactions":0,"matches":6511,"pathways":0,"proteins":6495,"proteomes":1366,"sets":1,"structural_models":{"alphafold":1174},"structures":9,"taxa":4439},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":4713},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5lzn","name":"-TIP microtubule-binding domain"}}}