This is a family of uncharacterised proteins. The structure of a hypothetical protein from Pseudomonas aeruginosa has shown it to adopt an alpha/beta fold, placing it in the Endonuclease superfamily/clan of restriction endonucleases.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00066699":{"PMID":22638584,"ISBN":null,"volume":"40","issue":"15","year":2012,"title":"Sequence, structure and functional diversity of PD-(D/E)XK phosphodiesterase superfamily.","URL":null,"raw_pages":"7016-45","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Steczkiewicz K","Muszewska A","Knizewski L","Rychlewski L","Ginalski K."],"DOI_URL":"http://dx.doi.org/10.1093/nar/gks382"}},"set_info":{"accession":"CL0236","name":"PDDEXK"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":386,"pathways":0,"proteins":386,"proteomes":382,"sets":1,"structural_models":{"alphafold":212},"structures":1,"taxa":471},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":15,"alignment:full":56},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1y0k","name":"Structure of Protein of Unknown Function PA4535 from Pseudomonas aeruginosa strain PAO1, Monooxygenase Superfamily"}}}