{"metadata":{"accession":"PF08681","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR014795","hierarchy":null,"name":{"name":"Antitoxin TacA 1-like","short":"TacA1"},"description":[{"text":"<p>This protein family includes Antitoxin TacA 1 from Salmonella typhimurium and similar short sequences mainly found in bacteria. TacA1, the antitoxin component of a type II toxin -antitoxin (TA) system, counteracts the toxic effect of cognate toxin TacT1. TacT1 is active in complex with its antitoxin, acetylation of this antitoxin upregulates the acetylation of tRNAs by TacT1 [[cite:PUB00158919],[cite:PUB00158918]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00158918":{"PMID":28559487,"ISBN":null,"volume":"8","issue":"3","year":2017,"title":"A Toxin Involved in <i>Salmonella</i> Persistence Regulates Its Activity by Acetylating Its Cognate Antitoxin, a Modification Reversed by CobB Sirtuin Deacetylase.","URL":null,"raw_pages":"e00708-17","medline_journal":"mBio","ISO_journal":"mBio","authors":["VanDrisse CM","Parks AR","Escalante-Semerena JC."],"DOI_URL":"https://doi.org/10.1128/mBio.00708-17"},"PUB00160187":{"PMID":30612860,"ISBN":null,"volume":"27","issue":"3","year":2019,"title":"Crystal Structure of the Enterohemorrhagic Escherichia coli AtaT-AtaR Toxin-Antitoxin Complex.","URL":null,"raw_pages":"476-484.e3","medline_journal":"Structure","ISO_journal":"Structure","authors":["Yashiro Y","Yamashita S","Tomita K."],"DOI_URL":"https://doi.org/10.1016/j.str.2018.11.005"},"PUB00160188":{"PMID":30718814,"ISBN":null,"volume":"15","issue":"3","year":2019,"title":"Mechanism of regulation and neutralization of the AtaR-AtaT toxin-antitoxin system.","URL":null,"raw_pages":"285-294","medline_journal":"Nat Chem Biol","ISO_journal":"Nat Chem Biol","authors":["Jurenas D","Van Melderen L","Garcia-Pino A."],"DOI_URL":"https://doi.org/10.1038/s41589-018-0216-z"},"PUB00160189":{"PMID":38538913,"ISBN":null,"volume":"31","issue":"7","year":2024,"title":"Molecular stripping underpins derepression of a toxin-antitoxin system.","URL":null,"raw_pages":"1050-1060","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Grabe GJ","Giorgio RT","Wieczor M","Gollan B","Sargen M","Orozco M","Hare SA","Helaine S."],"DOI_URL":"https://doi.org/10.1038/s41594-024-01253-2"},"PUB00158919":{"PMID":34556858,"ISBN":null,"volume":"17","issue":"12","year":2021,"title":"Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing.","URL":null,"raw_pages":"1296-1304","medline_journal":"Nat Chem Biol","ISO_journal":"Nat Chem Biol","authors":["Grabe GJ","Giorgio RT","Hall AMJ","Morgan RML","Dubois L","Sisley TA","Rycroft JA","Hare SA","Helaine S."],"DOI_URL":"https://doi.org/10.1038/s41589-021-00862-y"}},"set_info":{"accession":"CL0057","name":"Met_repress"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":4038,"pathways":0,"proteins":4037,"proteomes":2654,"sets":1,"structural_models":{"alphafold":2682},"structures":14,"taxa":4728},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":2047},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7zg6","name":"TacA1 antitoxin"}}}