{"metadata":{"accession":"PF08593","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013902","hierarchy":null,"name":{"name":"Mug135-like, C-terminal domain","short":"Mug135_C"},"description":[{"text":"<p>This entry represents the C-terminal domain found in Meiotically up-regulated gene 135 protein from Schizosaccharomyces pombe (Mug135, also known as Tdk1, O74876) and similar fungal proteins that are annotated as meiotically up-regulated gene products. Mug135 is a killer meiotic driver (KMD), a selfish genetic element that by selectively kills meiotic products lacking its gene, thereby promoting its own propagation. This protein exists in a nontoxic tetrameric form during vegetative growth and meiosis but transforms into a distinct toxic form in spores [[cite:PUB00159004],[cite:PUB00159007]]. These proteins generally contain a long coiled-coil region with this domain found at the C-terminus.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00159004":{"PMID":39485795,"ISBN":null,"volume":"121","issue":"45","year":2024,"title":"A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring.","URL":null,"raw_pages":"e2408347121","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Hua Y","Zhang J","Yang MY","Zhang FY","Ren JY","Lyu XH","Ding Y","Suo F","Shao GC","Li J","Dong MQ","Ye K","Du LL."],"DOI_URL":"https://doi.org/10.1073/pnas.2408347121"},"PUB00159007":{"PMID":39485800,"ISBN":null,"volume":"121","issue":"45","year":2024,"title":"Structural duality enables a single protein to act as a toxin-antidote pair for meiotic drive.","URL":null,"raw_pages":"e2408618121","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Hua Y","Zhang J","Yang MY","Ren JY","Suo F","Liang L","Dong MQ","Ye K","Du LL."],"DOI_URL":"https://doi.org/10.1073/pnas.2408618121"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":13,"interactions":0,"matches":572,"pathways":0,"proteins":570,"proteomes":181,"sets":0,"structural_models":{"alphafold":472},"structures":2,"taxa":487},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":169,"alignment:full":468},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}