{"metadata":{"accession":"PF08590","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013899","hierarchy":null,"name":{"name":"Domain of unknown function (DUF1771)","short":"DUF1771"},"description":[{"text":"<p>This domain is highly charged and may represent a small helical extension of the Smr domain ([pfam:PF01713]), known as N-ext, whose function is not yet clear [[cite:PUB00098095]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00098095":{"PMID":32234470,"ISBN":null,"volume":"30","issue":"13","year":2020,"title":"NONU-1 Encodes a Conserved Endonuclease Required for mRNA Translation Surveillance.","URL":null,"raw_pages":"4321-4331.e4","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Glover ML","Burroughs AM","Monem PC","Egelhofer TA","Pule MN","Aravind L","Arribere JA."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":237,"interactions":0,"matches":7427,"pathways":0,"proteins":7421,"proteomes":2861,"sets":0,"structural_models":{"alphafold":5346},"structures":0,"taxa":7508},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":175,"alignment:full":5488},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}