{"metadata":{"accession":"PF08574","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013883","hierarchy":null,"name":{"name":"Transcription factor Iwr1","short":"Iwr1"},"description":[{"text":"<p>Iwr1 is involved in transcription from polymerase II  promoters; it interacts with with most of the polymerase II  subunits [[cite:PUB00054162]]. Deletion of this protein results in  hypersensitivity to the K1 killer toxin [[cite:PUB00033286]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00033656":{"PMID":11805826,"ISBN":null,"volume":"415","issue":"6868","year":2002,"title":"Functional organization of the yeast proteome by systematic analysis of protein complexes.","URL":null,"raw_pages":"141-7","medline_journal":"Nature","ISO_journal":"Nature","authors":["Gavin AC","Bosche M","Krause R","Grandi P","Marzioch M","Bauer A","Schultz J","Rick JM","Michon AM","Cruciat CM","Remor M","Hofert C","Schelder M","Brajenovic M","Ruffner H","Merino A","Klein K","Hudak M","Dickson D","Rudi T","Gnau V","Bauch A","Bastuck S","Huhse B","Leutwein C","Heurtier MA","Copley RR","Edelmann A","Querfurth E","Rybin V","Drewes G","Raida M","Bouwmeester T","Bork P","Seraphin B","Kuster B","Neubauer G","Superti-Furga G."],"DOI_URL":"http://dx.doi.org/10.1038/415141a"},"PUB00054162":{"PMID":19679657,"ISBN":null,"volume":"284","issue":"42","year":2009,"title":"The yeast RNA polymerase II-associated factor Iwr1p is involved in the basal and regulated transcription of specific genes.","URL":null,"raw_pages":"28958-67","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Peiro-Chova L","Estruch F."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M109.012153"},"PUB00033286":{"PMID":12663529,"ISBN":null,"volume":"163","issue":"3","year":2003,"title":"A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin.","URL":null,"raw_pages":"875-94","medline_journal":"Genetics","ISO_journal":"Genetics","authors":["Page N","Gerard-Vincent M","Menard P","Beaulieu M","Azuma M","Dijkgraaf GJ","Li H","Marcoux J","Nguyen T","Dowse T","Sdicu AM","Bussey H."],"DOI_URL":"http://intl.genetics.org/cgi/content/abstract/163/3/875"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":40,"interactions":0,"matches":3273,"pathways":0,"proteins":3272,"proteomes":2883,"sets":0,"structural_models":{"alphafold":2793},"structures":0,"taxa":7650},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":89,"alignment:full":2497},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}