{"metadata":{"accession":"PF08552","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013862","hierarchy":null,"name":{"name":"Inositolphosphorylceramide synthase subunit Kei1","short":"Kei1"},"description":[{"text":"<p>Kei1 is a subunit of Saccharomyces cerevisiae inositol phosphorylceramide (IPC) synthase [[cite:PUB00092487]]. It is localised to the Golgi and is cleaved by the late Golgi processing endopeptidase Kex2 [[cite:PUB00092487]].  Kei1 is essential for both the activity and the Golgi localization of IPC synthase [[cite:PUB00092487]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00019458":{"PMID":14690591,"ISBN":null,"volume":"12","issue":"6","year":2003,"title":"Assigning function to yeast proteins by integration of technologies.","URL":null,"raw_pages":"1353-65","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Hazbun TR","Malmstrom L","Anderson S","Graczyk BJ","Fox B","Riffle M","Sundin BA","Aranda JD","McDonald WH","Chiu CH","Snydsman BE","Bradley P","Muller EG","Fields S","Baker D","Yates JR 3rd","Davis TN."],"DOI_URL":"http://dx.doi.org/10.1016/S1097-2765(03)00476-3"},"PUB00092487":{"PMID":19726565,"ISBN":null,"volume":"20","issue":"20","year":2009,"title":"Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization.","URL":null,"raw_pages":"4444-57","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Sato K","Noda Y","Yoda K."],"DOI_URL":"https://doi.org/10.1091/mbc.e09-03-0235"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":21,"interactions":0,"matches":1444,"pathways":0,"proteins":1407,"proteomes":1348,"sets":0,"structural_models":{"alphafold":1183},"structures":3,"taxa":2795},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":67,"alignment:full":1151},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}