This entry represents an integral membrane domain found in eukaryotic proteins. [swissprot:Q12239], a Saccharomyces cerervisiae protein, has been shown to localise COP II vesicles [[cite:PUB00016470]]. This protein has a predicted structure which shows similiarity to the rhomboid proteases.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00016470":{"PMID":14562095,"ISBN":null,"volume":"425","issue":"6959","year":2003,"title":"Global analysis of protein localization in budding yeast.","URL":null,"raw_pages":"686-91","medline_journal":"Nature","ISO_journal":"Nature","authors":["Huh WK","Falvo JV","Gerke LC","Carroll AS","Howson RW","Weissman JS","O'Shea EK."],"DOI_URL":"http://dx.doi.org/10.1038/nature02026"}},"set_info":{"accession":"CL0207","name":"Rhomboid-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":89,"interactions":0,"matches":6654,"pathways":0,"proteins":6596,"proteomes":3657,"sets":1,"structural_models":{"alphafold":5575},"structures":0,"taxa":9370},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":76,"alignment:full":5137},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}