{"metadata":{"accession":"PF08549","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013859","hierarchy":null,"name":{"name":"SWI/SNF and RSC complexes subunit Ssr4 N-terminal","short":"SWI-SNF_Ssr4_N"},"description":[{"text":"<p>This entry represents the N-terminal domain of SWI/SNF and RSC complexes subunit Ssr4 from S. pombe, a essential member of the chromatin structure remodelling complex (RSC) and the SWI/SNF complex [[cite:PUB00066307],[cite:PUB00101211]]. The structure of this domain revealed that it has a novel fold comprising an antiparallel beta-sheet of seven strands with alpha-helices on one side and random coil on the other [[cite:PUB00101211]]. It contains the highly conserved motif WxxxxxPxxGxxxxxxxxxxxxxxxDG. RSC is involved in transcription regulation and nucleosome positioning which controls, particularly, membrane and organelle development genes. The ATP-dependent chromatin remodelling complex SWI/SNF is required for the positive and negative regulation of gene expression of a large number of genes through the regulation of nucleosome remodelling [[cite:PUB00066307]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00066307":{"PMID":18622392,"ISBN":null,"volume":"15","issue":"8","year":2008,"title":"Fission yeast SWI/SNF and RSC complexes show compositional and functional differences from budding yeast.","URL":null,"raw_pages":"873-80","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Monahan BJ","Villen J","Marguerat S","Bahler J","Gygi SP","Winston F."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb.1452"},"PUB00101211":{"PMID":33263569,"ISBN":null,"volume":"76","issue":"Pt 12","year":2020,"title":"The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein.","URL":null,"raw_pages":"583-589","medline_journal":"Acta Crystallogr F Struct Biol Commun","ISO_journal":"Acta Crystallogr F Struct Biol Commun","authors":["Newman J","Nebl T","Van H","Peat TS."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":18,"interactions":0,"matches":1098,"pathways":0,"proteins":1093,"proteomes":1066,"sets":0,"structural_models":{"alphafold":907},"structures":3,"taxa":2251},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":28,"alignment:full":896},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7k7w","name":"The X-ray crystal structure of SSR4, an S. pombe chromatin remodelling protein: native"}}}