{"metadata":{"accession":"PF08520","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013726","hierarchy":null,"name":{"name":"Mitofissin","short":"Mitofissin"},"description":[{"text":"<p>This is a family of fungal proteins identified as mitochondrial fission factors (mitofissin, also referred to as Atg44) which are essential for mitophagy. Mitofissin directly binds to lipid membranes to drive mitochondrial fission required for mitophagy [[cite:PUB00151415]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151415":{"PMID":37192628,"ISBN":null,"volume":null,"issue":null,"year":2023,"title":"The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy.","URL":null,"raw_pages":"S1097-2765(23)00316-7","medline_journal":"Mol Cell","ISO_journal":"Mol Cell","authors":["Fukuda T","Furukawa K","Maruyama T","Yamashita SI","Noshiro D","Song C","Ogasawara Y","Okuyama K","Alam JM","Hayatsu M","Saigusa T","Inoue K","Ikeda K","Takai A","Chen L","Lahiri V","Okada Y","Shibata S","Murata K","Klionsky DJ","Noda NN","Kanki T."],"DOI_URL":"https://doi.org/10.1016/j.molcel.2023.04.022"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":28,"interactions":0,"matches":1787,"pathways":0,"proteins":1770,"proteomes":1272,"sets":0,"structural_models":{"alphafold":1470},"structures":1,"taxa":2767},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":197,"alignment:full":1411},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7ydo","name":"Crystal structure of Atg44"}}}