{"metadata":{"accession":"PF08512","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013719","hierarchy":null,"name":{"name":"Histone chaperone Rttp106-like, middle domain","short":"Rttp106-like_middle"},"description":[{"text":"<p>This Pleckstrin homology (PH) domain is found in the middle region of Rttp106, a histone chaperone involved in heterochromatin-mediated silencing [[cite:PUB00033392]]. It is also found in the final part of the middle domain of various FACT (facilitates chromatin transactions) complex subunits, such as Spt16 and either Pob3 (yeast) or the related SSRP1 (higher eukaryotes). This domain plays a role in DNA binding [[cite:PUB00101033],[cite:PUB00101035],[cite:PUB00101032]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00033392":{"PMID":16157874,"ISBN":null,"volume":"102","issue":"38","year":2005,"title":"Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing.","URL":null,"raw_pages":"13410-5","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Huang S","Zhou H","Katzmann D","Hochstrasser M","Atanasova E","Zhang Z."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0506176102"},"PUB00101035":{"PMID":26687053,"ISBN":null,"volume":"5","issue":null,"year":2015,"title":"Crystal Structure of Human SSRP1 Middle Domain Reveals a Role in DNA Binding.","URL":null,"raw_pages":"18688","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Zhang W","Zeng F","Liu Y","Shao C","Li S","Lv H","Shi Y","Niu L","Teng M","Li X."],"DOI_URL":null},"PUB00101033":{"PMID":23417676,"ISBN":null,"volume":"288","issue":"15","year":2013,"title":"Structure of the Spt16 middle domain reveals functional features of the histone chaperone FACT.","URL":null,"raw_pages":"10188-94","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Kemble DJ","Whitby FG","Robinson H","McCullough LL","Formosa T","Hill CP."],"DOI_URL":null},"PUB00101032":{"PMID":31775157,"ISBN":null,"volume":"577","issue":"7790","year":2020,"title":"FACT caught in the act of manipulating the nucleosome.","URL":null,"raw_pages":"426-431","medline_journal":"Nature","ISO_journal":"Nature","authors":["Liu Y","Zhou K","Zhang N","Wei H","Tan YZ","Zhang Z","Carragher B","Potter CS","D'Arcy S","Luger K."],"DOI_URL":null}},"set_info":{"accession":"CL0266","name":"PH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":244,"interactions":0,"matches":10251,"pathways":0,"proteins":10226,"proteomes":3420,"sets":1,"structural_models":{"alphafold":8633},"structures":36,"taxa":9039},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":176,"alignment:full":7771},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}