This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation [[cite:PUB00075404]]. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins [[cite:PUB00098082]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00075404":{"PMID":21504829,"ISBN":null,"volume":"42","issue":"2","year":2011,"title":"Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.","URL":null,"raw_pages":"160-71","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Stewart EV","Nwosu CC","Tong Z","Roguev A","Cummins TD","Kim DU","Hayles J","Park HO","Hoe KL","Powell DW","Krogan NJ","Espenshade PJ."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2011.02.035"},"PUB00098082":{"PMID":29355480,"ISBN":null,"volume":"7","issue":null,"year":2018,"title":"Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system.","URL":null,"raw_pages":null,"medline_journal":"Elife","ISO_journal":"Elife","authors":["Yang X","Arines FM","Zhang W","Li M."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":20,"interactions":0,"matches":1353,"pathways":0,"proteins":1326,"proteomes":1282,"sets":0,"structural_models":{"alphafold":1116},"structures":0,"taxa":2736},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":56,"alignment:full":1077},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}