{"metadata":{"accession":"PF08495","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013702","hierarchy":null,"name":{"name":"FIST N domain","short":"FIST"},"description":[{"text":"<p>The FIST N domain is a novel sensory domain, which is present in signal transduction proteins from Bacteria, Archaea and Eukarya. Chromosomal proximity of FIST-encoding genes to those coding for proteins involved in amino acid metabolism and transport suggest that FIST domains bind small ligands, such as amino acids [[cite:PUB00044261]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00044261":{"PMID":17855421,"ISBN":null,"volume":"23","issue":"19","year":2007,"title":"FIST: a sensory domain for diverse signal transduction pathways in prokaryotes and ubiquitin signaling in eukaryotes.","URL":null,"raw_pages":"2518-21","medline_journal":"Bioinformatics","ISO_journal":"Bioinformatics","authors":["Borziak K","Zhulin IB."],"DOI_URL":"http://dx.doi.org/10.1093/bioinformatics/btm384"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":104,"interactions":0,"matches":6781,"pathways":0,"proteins":6777,"proteomes":5036,"sets":0,"structural_models":{"alphafold":4552},"structures":0,"taxa":8763},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":246,"alignment:full":3771},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}