{"metadata":{"accession":"PF08409","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013618","hierarchy":null,"name":{"name":"Protein O-mannosyl-transferase TMTC, DUF1736","short":"TMTC_DUF1736"},"description":[{"text":"<p>This domain of unknown function is found in O-mannosyl -transferases TMTC1-4, and constitutes a loop between TM7 and TM8 located in the ER lumen that contains a small hydrophobic, but not membrane-embedded helix. This loop is critical for catalysis and binding of ligands, especially the lipid-linked sugar moiety [[cite:PUB00098068]]. TMTCs transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases acting primarily on the cadherin superfamily; each member has distinct roles in decorating the cadherin domains with O-linked mannose glycans at specific regions. These proteins also act as O-mannosyl-transferase on other proteins such as PDIA3 [[cite:PUB00098069]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098069":{"PMID":28973932,"ISBN":null,"volume":"114","issue":"42","year":2017,"title":"Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins.","URL":null,"raw_pages":"11163-11168","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Larsen ISB","Narimatsu Y","Joshi HJ","Siukstaite L","Harrison OJ","Brasch J","Goodman KM","Hansen L","Shapiro L","Honig B","Vakhrushev SY","Clausen H","Halim A."],"DOI_URL":null},"PUB00098068":{"PMID":33436046,"ISBN":null,"volume":"16","issue":"1","year":2021,"title":"Conserved sequence motifs in human TMTC1, TMTC2, TMTC3, and TMTC4, new O-mannosyltransferases from the GT-C/PMT clan, are rationalized as ligand binding sites.","URL":null,"raw_pages":"4","medline_journal":"Biol Direct","ISO_journal":"Biol Direct","authors":["Eisenhaber B","Sinha S","Jadalanki CK","Shitov VA","Tan QW","Sirota FL","Eisenhaber F."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1307,"interactions":0,"matches":6939,"pathways":0,"proteins":6936,"proteomes":1367,"sets":0,"structural_models":{"alphafold":6079},"structures":0,"taxa":4389},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":77,"alignment:full":5382},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}