{"metadata":{"accession":"PF08401","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013610","hierarchy":null,"name":{"name":"N-terminal domain of anti-restriction factor ArdC","short":"ArdcN"},"description":[{"text":"<p>This is the ssDNA binding domain of anti-restriction factor ArdC deployed by plasmids and phages in polyvalent proteins related to the BHD domains of XPC/Rad4  and the Tc-38 domain found in kinetoplastid minicircle binding proteins [[cite:PUB00098071],[cite:PUB00091133],[cite:PUB00098072]]. The structure of this domain is composed of three alpha-helices and a three-stranded beta-sheet that supports a long and protuberant beta-hairpin [[cite:PUB00098072]]. This domain is also found in the N-terminal region of the RP4 TraC1 primase [[cite:PUB00043496]], together with the Toprim domain (pfam:PF01751, pfam:PF13362 and pfam:PF13662).</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091133":{"PMID":28559295,"ISBN":null,"volume":"199","issue":"15","year":2017,"title":"Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements.","URL":null,"raw_pages":null,"medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Iyer LM","Burroughs AM","Anand S","de Souza RF","Aravind L."],"DOI_URL":"https://doi.org/10.1128/JB.00245-17"},"PUB00043496":{"PMID":10686096,"ISBN":null,"volume":"296","issue":"4","year":2000,"title":"Antirestriction protein Ard (Type C) encoded by IncW plasmid pSa has a high similarity to the \"protein transport\" domain of TraC1 primase of promiscuous plasmid RP4.","URL":null,"raw_pages":"969-77","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["Belogurov AA","Delver EP","Agafonova OV","Belogurova NG","Lee LY","Kado CI."],"DOI_URL":"http://dx.doi.org/10.1006/jmbi.1999.3493"},"PUB00098071":{"PMID":30396152,"ISBN":null,"volume":"9","issue":null,"year":2018,"title":"Unexpected Evolution of Lesion-Recognition Modules in Eukaryotic NER and Kinetoplast DNA Dynamics Proteins from Bacterial Mobile Elements.","URL":null,"raw_pages":"192-208","medline_journal":"iScience","ISO_journal":"iScience","authors":["Krishnan A","Burroughs AM","Iyer LM","Aravind L."],"DOI_URL":null},"PUB00098072":{"PMID":32348296,"ISBN":null,"volume":"16","issue":"4","year":2020,"title":"ArdC, a ssDNA-binding protein with a metalloprotease domain, overpasses the recipient hsdRMS restriction system broadening conjugation host range.","URL":null,"raw_pages":"e1008750","medline_journal":"PLoS Genet","ISO_journal":"PLoS Genet","authors":["Gonzalez-Montes L","Del Campo I","Garcillan-Barcia MP","de la Cruz F","Moncalian G."],"DOI_URL":null}},"set_info":{"accession":"CL0700","name":"ArdcN"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":194,"interactions":0,"matches":6494,"pathways":0,"proteins":6492,"proteomes":4027,"sets":1,"structural_models":{"alphafold":4276},"structures":2,"taxa":6807},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":81,"alignment:full":3537},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}