{"metadata":{"accession":"PF08350","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013561","hierarchy":null,"name":{"name":"Methanogenesis regulatory protein FilR1, middle domain","short":"FilR1_middle"},"description":[{"text":"<p>This archaeal domain of unknown function has been found at the middle of Methanogenesis regulatory protein FilR1 [[cite:PUB00091155],[cite:PUB00098067]] and at the C-terminus of archaeal proteins, including several transcriptional regulators of the ArsR family (see [pfam:PF01022]). FilR1 is a member of the two-component regulatory system FilI/FilRs which is involved in the regulation of methanogenesis.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091155":{"PMID":29263101,"ISBN":null,"volume":"200","issue":"7","year":2018,"title":"Phyletic Distribution and Lineage-Specific Domain Architectures of Archaeal Two-Component Signal Transduction Systems.","URL":null,"raw_pages":null,"medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Galperin MY","Makarova KS","Wolf YI","Koonin EV."],"DOI_URL":"https://doi.org/10.1128/JB.00681-17"},"PUB00098067":{"PMID":24748383,"ISBN":null,"volume":"9","issue":"4","year":2014,"title":"Characterization of an archaeal two-component system that regulates methanogenesis in Methanosaeta harundinacea.","URL":null,"raw_pages":"e95502","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Li J","Zheng X","Guo X","Qi L","Dong X."],"DOI_URL":null}},"set_info":{"accession":"CL0479","name":"PLD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":44,"interactions":0,"matches":2193,"pathways":0,"proteins":2179,"proteomes":403,"sets":1,"structural_models":{"alphafold":2031},"structures":0,"taxa":674},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":161,"alignment:full":785},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}