{"metadata":{"accession":"PF08227","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013183","hierarchy":null,"name":{"name":"DASH complex subunit Hsk3 like","short":"DASH_Hsk3"},"description":[{"text":"<p>The DASH complex is a ~10 subunit microtubule-binding complex that is transferred to the kinetochore prior to mitosis [[cite:PUB00017174]]. In Saccharomyces cerevisiae DASH forms both rings and spiral structures on microtubules in vitro [[cite:PUB00033281],[cite:PUB00033282]].  This family also includes several higher eukaryotic proteins. However, other DASH subunits do not appear to be conserved in higher eukaryotes.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00033281":{"PMID":15640796,"ISBN":null,"volume":"12","issue":"2","year":2005,"title":"The yeast DASH complex forms closed rings on microtubules.","URL":null,"raw_pages":"138-43","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Miranda JJ","De Wulf P","Sorger PK","Harrison SC."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb896"},"PUB00017174":{"PMID":11799062,"ISBN":null,"volume":"16","issue":"2","year":2002,"title":"The mitotic spindle is required for loading of the DASH complex onto the kinetochore.","URL":null,"raw_pages":"183-97","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Li Y","Bachant J","Alcasabas AA","Wang Y","Qin J","Elledge SJ."],"DOI_URL":"http://dx.doi.org/10.1101/gad.959402"},"PUB00033282":{"PMID":15664196,"ISBN":null,"volume":"17","issue":"2","year":2005,"title":"Formation of a dynamic kinetochore- microtubule interface through assembly of the Dam1 ring complex.","URL":null,"raw_pages":"277-90","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Westermann S","Avila-Sakar A","Wang HW","Niederstrasser H","Wong J","Drubin DG","Nogales E","Barnes G."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2004.12.019"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":20,"interactions":0,"matches":1859,"pathways":0,"proteins":1859,"proteomes":1708,"sets":0,"structural_models":{"alphafold":1641},"structures":3,"taxa":4301},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":40,"alignment:full":1506},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}