{"metadata":{"accession":"PF08214","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR016849","hierarchy":null,"name":{"name":"Histone acetyltransferase KAT11-type domain","short":"HAT_KAT11"},"description":[{"text":"<p>This entry represents a histone acetyltransferase catalytic domain found in fungal proteins, including RTT109 (also known as KAT11) from budding and fission yeasts and Candida species. This domain catalyses the acetylation of lysine residues on histone H3, including H3K56, H3K9, H3K14, H3K23 and H3K27 [[cite:PUB00045009],[cite:PUB00042670]]. The domain functions within a complex with histone chaperones such as VPS75 that regulate substrate specificity [[cite:PUB00051225]]. Acetylation of H3K56 by this domain promotes nucleosome assembly, DNA repair and transcriptional regulation during S-phase [[cite:PUB00045009],[cite:PUB00042670]]. The domain is also found in other histone acetyltransferases including p300/CBP which share a similar fold but differ in catalytic properties and cofactor requirements [[cite:PUB00051225]]. Members of this family show conservation across most eukaryotic fungi.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00045009":{"PMID":17046836,"ISBN":null,"volume":"281","issue":"49","year":2006,"title":"Rtt109 is required for proper H3K56 acetylation: a chromatin mark associated with the elongating RNA polymerase II.","URL":null,"raw_pages":"37270-4","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Schneider J","Bajwa P","Johnson FC","Bhaumik SR","Shilatifard A."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.C600265200"},"PUB00042670":{"PMID":17272723,"ISBN":null,"volume":"315","issue":"5812","year":2007,"title":"Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication.","URL":null,"raw_pages":"653-5","medline_journal":"Science","ISO_journal":"Science","authors":["Han J","Zhou H","Horazdovsky B","Zhang K","Xu RM","Zhang Z."],"DOI_URL":"http://dx.doi.org/10.1126/science.1133234"},"PUB00163877":{"PMID":20601951,"ISBN":null,"volume":"16","issue":"7","year":2010,"title":"Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy.","URL":null,"raw_pages":"774-80","medline_journal":"Nat Med","ISO_journal":"Nat Med","authors":["Wurtele H","Tsao S","Lepine G","Mullick A","Tremblay J","Drogaris P","Lee EH","Thibault P","Verreault A","Raymond M."],"DOI_URL":"https://doi.org/10.1038/nm.2175"},"PUB00051225":{"PMID":18568037,"ISBN":null,"volume":"15","issue":"7","year":2008,"title":"Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP.","URL":null,"raw_pages":"738-45","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Tang Y","Holbert MA","Wurtele H","Meeth K","Rocha W","Gharib M","Jiang E","Thibault P","Verreault A","Verrault A","Cole PA","Marmorstein R."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb.1448"}},"set_info":{"accession":"CL0257","name":"Acetyltrans"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":30,"interactions":0,"matches":2178,"pathways":0,"proteins":1484,"proteomes":1444,"sets":1,"structural_models":{"alphafold":1224},"structures":19,"taxa":3025},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":18,"alignment:full":1919},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8gq3","name":"RTT109 mutant from Candida albicans"}}}