{"metadata":{"accession":"PF07894","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR012461","hierarchy":null,"name":{"name":"Scaffolding anchor of CK1 domain","short":"SACK1"},"description":[{"text":"<p>This entry represents the scaffolding anchor of CK1 domain (SACK1 domain) found in the FAM83 family, which includes FAM83A-H. This domain was formerly known as DUF1669 and it has been identified as a CK1 binding domain, which allows the correct subcellular localisation of both FAM83 proteins and the CK1 binding partners and their function [[cite:PUB00155374]]. These proteins are involved in diverse biological processes, depending on their subcellular localisation and binding partners. FAM83A-H interact with the alpha and alpha-like isoforms of CK1, while FAM83A, B, E, and H also interact with the delta and epsilon isoforms of CK1. FAM83 members have  function as intermediaries in EGFR/RAS signalling [[cite:PUB00084963]]. FAM83D has been reported to localise to the mitotic spindle and interact with the chromokinesin kinesin family member 22 (KIF22, also called Kid) [[cite:PUB00124155]]. FAM83G, also known as PAWS1 interacts with the transcription factor SMAD1 and promotes the transcription of non-canonical bone morphogenetic protein (BMP) target genes [[cite:PUB00155375]]. FAM83H mutations have been associated with amelogenesis imperfecta [[cite:PUB00092186]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00124155":{"PMID":18485706,"ISBN":null,"volume":"18","issue":"10","year":2008,"title":"The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle.","URL":null,"raw_pages":"723-729","medline_journal":"Curr Biol","ISO_journal":"Curr Biol","authors":["Santamaria A","Nagel S","Sillje HHW","Nigg EA."],"DOI_URL":null},"PUB00155374":{"PMID":29789297,"ISBN":null,"volume":"11","issue":"531","year":2018,"title":"The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms.","URL":null,"raw_pages":"eaao2341","medline_journal":"Sci Signal","ISO_journal":"Sci Signal","authors":["Fulcher LJ","Bozatzi P","Tachie-Menson T","Wu KZL","Cummins TD","Bufton JC","Pinkas DM","Dunbar K","Shrestha S","Wood NT","Weidlich S","Macartney TJ","Varghese J","Gourlay R","Campbell DG","Dingwell KS","Smith JC","Bullock AN","Sapkota GP."],"DOI_URL":"https://doi.org/10.1126/scisignal.aao2341"},"PUB00084963":{"PMID":27221039,"ISBN":null,"volume":"7","issue":"32","year":2016,"title":"FAM83 proteins: Fostering new interactions to drive oncogenic signaling and therapeutic resistance.","URL":null,"raw_pages":"52597-52612","medline_journal":"Oncotarget","ISO_journal":"Oncotarget","authors":["Bartel CA","Parameswaran N","Cipriano R","Jackson MW."],"DOI_URL":"https://doi.org/10.18632/oncotarget.9544"},"PUB00155375":{"PMID":24554596,"ISBN":null,"volume":"4","issue":null,"year":2014,"title":"Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling.","URL":null,"raw_pages":"130210","medline_journal":"Open Biol","ISO_journal":"Open Biol","authors":["Vogt J","Dingwell KS","Herhaus L","Gourlay R","Macartney T","Campbell D","Smith JC","Sapkota GP."],"DOI_URL":"https://doi.org/10.1098/rsob.130210"},"PUB00092186":{"PMID":18252228,"ISBN":null,"volume":"82","issue":"2","year":2008,"title":"FAM83H mutations in families with autosomal-dominant hypocalcified amelogenesis imperfecta.","URL":null,"raw_pages":"489-94","medline_journal":"Am J Hum Genet","ISO_journal":"Am. J. Hum. Genet.","authors":["Kim JW","Lee SK","Lee ZH","Park JC","Lee KE","Lee MH","Park JT","Seo BM","Hu JC","Simmer JP."],"DOI_URL":"https://doi.org/10.1016/j.ajhg.2007.09.020"}},"set_info":{"accession":"CL0479","name":"PLD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":43,"interactions":0,"matches":7530,"pathways":0,"proteins":7127,"proteomes":767,"sets":1,"structural_models":{"alphafold":6117},"structures":13,"taxa":2356},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":51,"alignment:full":6320},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5lzk","name":"Structure of the domain of unknown function DUF1669 from human FAM83B"}}}