{"metadata":{"accession":"PF07869","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR012451","hierarchy":null,"name":{"name":"Protein of unknown function (DUF1656)","short":"DUF1656"},"description":[{"text":"<p>This entry represents a putative component of efflux pumps that comprise MFP and FUSC proteins. Several members are in an operon with and have similar mutants phenotypes as an RND efflux pump and a fusaric acid resistance-like protein [[cite:PUB00093610]]. This system is involved in transporting diverse substrates including 4-hydroxybenzoate and octanoate [[cite:PUB00106931]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00093610":{"PMID":29769716,"ISBN":null,"volume":"557","issue":"7706","year":2018,"title":"Mutant phenotypes for thousands of bacterial genes of unknown function.","URL":null,"raw_pages":"503-509","medline_journal":"Nature","ISO_journal":"Nature","authors":["Price MN","Wetmore KM","Waters RJ","Callaghan M","Ray J","Liu H","Kuehl JV","Melnyk RA","Lamson JS","Suh Y","Carlson HK","Esquivel Z","Sadeeshkumar H","Chakraborty R","Zane GM","Rubin BE","Wall JD","Visel A","Bristow J","Blow MJ","Arkin AP","Deutschbauer AM."],"DOI_URL":null},"PUB00106931":{"PMID":23774757,"ISBN":null,"volume":"9","issue":null,"year":2013,"title":"Dissecting a complex chemical stress: chemogenomic profiling of plant hydrolysates.","URL":null,"raw_pages":"674","medline_journal":"Mol Syst Biol","ISO_journal":"Mol Syst Biol","authors":["Skerker JM","Leon D","Price MN","Mar JS","Tarjan DR","Wetmore KM","Deutschbauer AM","Baumohl JK","Bauer S","Ibanez AB","Mitchell VD","Wu CH","Hu P","Hazen T","Arkin AP."],"DOI_URL":null}},"set_info":{"accession":"CL0703","name":"YtcA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":4265,"pathways":0,"proteins":4265,"proteomes":2613,"sets":1,"structural_models":{"alphafold":2687},"structures":0,"taxa":3566},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":76,"alignment:full":1223},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}