This domain is found in proteins expressed by bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues. One protein containing this domain is immunity protein SdpI (swiss:O32241) from Bacillus subtilis, which provides protection for the cell against the toxic effects of its own SdpC killing factor, and also functions as a receptor/signal transduction protein [[cite:PUB00055038]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00055038":{"PMID":16469701,"ISBN":null,"volume":"124","issue":"3","year":2006,"title":"A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin.","URL":null,"raw_pages":"549-59","medline_journal":"Cell","ISO_journal":"Cell","authors":["Ellermeier CD","Hobbs EC","Gonzalez-Pastor JE","Losick R."],"DOI_URL":"http://dx.doi.org/10.1016/j.cell.2005.11.041"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":19,"interactions":0,"matches":4912,"pathways":0,"proteins":4912,"proteomes":4034,"sets":0,"structural_models":{"alphafold":3097},"structures":0,"taxa":6352},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":141,"alignment:full":2462},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}