{"metadata":{"accession":"PF07849","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR012440","hierarchy":null,"name":{"name":"Helical membrane plugin","short":"HMP"},"description":[{"text":"<p>This entry represents the helical membrane plugin (HMP) domain found in a group of uncharacterised prokaryotic proteins, including the [NiFe]-hydrogenase Huc from Mycobacterium smegmatis [[cite:PUB00161758]]. It is involved in the construction of oxidoreductases in prokaryotes, which allows quinone channelling between the membrane and various redox catalytic subunits [[cite:PUB00161759]]. It was previously known as DUF1641.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00161759":{"PMID":40855134,"ISBN":null,"volume":null,"issue":null,"year":2025,"title":"A scaffold for quinone channeling between membrane and soluble bacterial oxidoreductases.","URL":null,"raw_pages":null,"medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Broc M","Cherrier MV","Uzel A","Arias-Cartin R","Arnoux P","Brasseur G","Seduk F","Guigliarelli B","Legrand P","Pierrel F","Schoehn G","Mate MJ","Martin L","Grimaldi S","Nicolet Y","Magalon A","Walburger A."],"DOI_URL":"https://doi.org/10.1038/s41594-025-01607-4"},"PUB00161758":{"PMID":36890228,"ISBN":null,"volume":"615","issue":"7952","year":2023,"title":"Structural basis for bacterial energy extraction from atmospheric hydrogen.","URL":null,"raw_pages":"541-547","medline_journal":"Nature","ISO_journal":"Nature","authors":["Grinter R","Kropp A","Venugopal H","Senger M","Badley J","Cabotaje PR","Jia R","Duan Z","Huang P","Stripp ST","Barlow CK","Belousoff M","Shafaat HS","Cook GM","Schittenhelm RB","Vincent KA","Khalid S","Berggren G","Greening C."],"DOI_URL":"https://doi.org/10.1038/s41586-023-05781-7"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":1961,"pathways":0,"proteins":1961,"proteomes":1449,"sets":0,"structural_models":{"alphafold":1361},"structures":4,"taxa":2277},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":64,"alignment:full":870},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}