{"metadata":{"accession":"PF07798","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024461","hierarchy":null,"name":{"name":"Coiled-coil domain-containing protein 90-like","short":"CCDC90-like"},"description":[{"text":"<p>This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1 [[cite:PUB00097799],[cite:PUB00076354],[cite:PUB00097801]]. A study in mammals and in yeast homologue fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU [[cite:PUB00075452]], however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU [[cite:PUB00097799],[cite:PUB00097800]]. The role of CCDC90B proteins is still not known.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097800":{"PMID":26445506,"ISBN":null,"volume":"22","issue":"4","year":2015,"title":"MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter.","URL":null,"raw_pages":"533-5","medline_journal":"Cell Metab","ISO_journal":"Cell Metab","authors":["Vais H","Tanis JE","Muller M","Payne R","Mallilankaraman K","Foskett JK."],"DOI_URL":null},"PUB00076354":{"PMID":23178883,"ISBN":null,"volume":"14","issue":"12","year":2012,"title":"MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.","URL":null,"raw_pages":"1336-43","medline_journal":"Nat Cell Biol","ISO_journal":"Nat. Cell Biol.","authors":["Mallilankaraman K","Cardenas C","Doonan PJ","Chandramoorthy HC","Irrinki KM","Golenar T","Csordas G","Madireddi P","Yang J","Muller M","Miller R","Kolesar JE","Molgo J","Kaufman B","Hajnoczky G","Foskett JK","Madesh M."],"DOI_URL":"http://dx.doi.org/10.1038/ncb2622"},"PUB00075452":{"PMID":25565209,"ISBN":null,"volume":"21","issue":"1","year":2015,"title":"CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter.","URL":null,"raw_pages":"109-16","medline_journal":"Cell Metab","ISO_journal":"Cell Metab.","authors":["Paupe V","Prudent J","Dassa EP","Rendon OZ","Shoubridge EA."],"DOI_URL":"http://dx.doi.org/10.1016/j.cmet.2014.12.004"},"PUB00097799":{"PMID":27184846,"ISBN":null,"volume":"15","issue":"8","year":2016,"title":"MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics.","URL":null,"raw_pages":"1673-85","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Tomar D","Dong Z","Shanmughapriya S","Koch DA","Thomas T","Hoffman NE","Timbalia SA","Goldman SJ","Breves SL","Corbally DP","Nemani N","Fairweather JP","Cutri AR","Zhang X","Song J","Jana F","Huang J","Barrero C","Rabinowitz JE","Luongo TS","Schumacher SM","Rockman ME","Dietrich A","Merali S","Caplan J","Stathopulos P","Ahima RS","Cheung JY","Houser SR","Koch WJ","Patel V","Gohil VM","Elrod JW","Rajan S","Madesh M."],"DOI_URL":null},"PUB00097801":{"PMID":26976564,"ISBN":null,"volume":"113","issue":"13","year":2016,"title":"Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.","URL":null,"raw_pages":"E1872-80","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Chaudhuri D","Artiga DJ","Abiria SA","Clapham DE."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":96,"interactions":0,"matches":6782,"pathways":0,"proteins":6646,"proteomes":2866,"sets":0,"structural_models":{"alphafold":5610},"structures":1,"taxa":7214},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":81,"alignment:full":5294},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}