{"metadata":{"accession":"PF07774","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR011678","hierarchy":null,"name":{"name":"ER membrane protein complex subunit 1, second beta-propeller","short":"EMC1_C"},"description":[{"text":"<p>This is the second beta-propeller domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) [[cite:PUB00061987]]. EMC1 contains two eight-bladed beta-propellers and stabilises the entire EMC complex, contacting six of the remaining eight subunits [[cite:PUB00096682]]. The beta-propellers are in the lumen and may serve as a platform for recruitment of co-factors at the site of nascent protein insertion [[cite:PUB00096682]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00061987":{"PMID":19325107,"ISBN":null,"volume":"323","issue":"5922","year":2009,"title":"Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum.","URL":null,"raw_pages":"1693-7","medline_journal":"Science","ISO_journal":"Science","authors":["Jonikas MC","Collins SR","Denic V","Oh E","Quan EM","Schmid V","Weibezahn J","Schwappach B","Walter P","Weissman JS","Schuldiner M."],"DOI_URL":"http://dx.doi.org/10.1126/science.1167983"},"PUB00096682":{"PMID":32439656,"ISBN":null,"volume":"369","issue":"6502","year":2020,"title":"Structural basis for membrane insertion by the human ER membrane protein complex.","URL":null,"raw_pages":"433-436","medline_journal":"Science","ISO_journal":"Science","authors":["Pleiner T","Tomaleri GP","Januszyk K","Inglis AJ","Hazu M","Voorhees RM."],"DOI_URL":null}},"set_info":{"accession":"CL0186","name":"Beta_propeller"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":100,"interactions":0,"matches":4882,"pathways":0,"proteins":4701,"proteomes":3296,"sets":1,"structural_models":{"alphafold":3919},"structures":12,"taxa":8699},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":132,"alignment:full":3813},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}