This family includes sequences of largely unknown function but which share a number of features in common. They are expressed by bacterial species, and in many cases these bacteria are known to associate symbiotically with plants. Moreover, the majority are coded for by plasmids, which in many cases are known to confer on the organism the ability to interact symbiotically with leguminous plants. An example of such a plasmid is NGR234, which encodes Y4CF, a protein of unknown function that is a member of this family [[cite:PUB00004254]]. Other members of this family are expressed by organisms with a documented genomic similarity to plant symbionts [[cite:PUB00015202]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00015202":{"PMID":12271122,"ISBN":null,"volume":"99","issue":"20","year":2002,"title":"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.","URL":null,"raw_pages":"13148-53","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Paulsen IT","Seshadri R","Nelson KE","Eisen JA","Heidelberg JF","Read TD","Dodson RJ","Umayam L","Brinkac LM","Beanan MJ","Daugherty SC","Deboy RT","Durkin AS","Kolonay JF","Madupu R","Nelson WC","Ayodeji B","Kraul M","Shetty J","Malek J","Van Aken SE","Riedmuller S","Tettelin H","Gill SR","White O","Salzberg SL","Hoover DL","Lindler LE","Halling SM","Boyle SM","Fraser CM."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.192319099"},"PUB00004254":{"PMID":9163424,"ISBN":null,"volume":"387","issue":"6631","year":1997,"title":"Molecular basis of symbiosis between Rhizobium and legumes.","URL":null,"raw_pages":"394-401","medline_journal":"Nature","ISO_journal":"Nature","authors":["Freiberg C","Fellay R","Bairoch A","Broughton WJ","Rosenthal A","Perret X."],"DOI_URL":"http://dx.doi.org/10.1038/387394a0"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":683,"pathways":0,"proteins":683,"proteomes":385,"sets":0,"structural_models":{"alphafold":426},"structures":0,"taxa":553},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":241},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}