{"metadata":{"accession":"PF07648","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR002350","hierarchy":null,"name":{"name":"Kazal-type serine protease inhibitor domain","short":"Kazal_2"},"description":[{"text":"<p>Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Kazal_domain","extract":"<p>The <b>Kazal domain </b> is an evolutionary conserved protein domain usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0005","name":"Kazal"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1970,"interactions":0,"matches":81132,"pathways":0,"proteins":44505,"proteomes":1635,"sets":1,"structural_models":{"alphafold":37798,"bfvd":0},"structures":43,"taxa":5624},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":56494},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3pis","name":"Crystal Structure of Carcinoscorpius rotundicauda Serine Protease Inhibitor Domain 1"}}}