{"metadata":{"accession":"PF07603","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR011460","hierarchy":null,"name":{"name":"Lcl C-terminal domain","short":"Lcl_C"},"description":[{"text":"<p>This domain is found C-terminal in the Legionella collagen-like protein (Lcl) and related proteins mainly from bacteria. Lcl is an extracellular peripheral membrane protein that recognises sulphated glycosaminoglycans (GAGs) on the surface of eukaryotic cells, but also stimulates bacterial aggregation in response to divalent cations. This domain has a structural similarity to C-type lectins and is involved in glycan recognition [[cite:PUB00155456]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00155456":{"PMID":38106198,"ISBN":null,"volume":null,"issue":null,"year":2023,"title":"The <i>Legionella</i> collagen-like protein employs a unique binding mechanism for the recognition of host glycosaminoglycans.","URL":null,"raw_pages":"2023.12.10.570962","medline_journal":"bioRxiv","ISO_journal":"bioRxiv","authors":["Rehman S","Antonovic AK","McIntire IE","Zheng H","Cleaver L","Adams CO","Portlock T","Richardson K","Shaw R","Oregioni A","Mastroianni G","Whittaker SB","Kelly G","Fornili A","Cianciotto NP","Garnett JA."],"DOI_URL":"https://doi.org/10.1101/2023.12.10.570962"}},"set_info":{"accession":"CL0056","name":"C_Lectin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":336,"interactions":0,"matches":4653,"pathways":0,"proteins":3754,"proteomes":1558,"sets":1,"structural_models":{"alphafold":2459},"structures":2,"taxa":2898},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":127,"alignment:full":2507},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8q4e","name":"Structure of Legionella pneumophila Lcl C-terminal domain"}}}