{"metadata":{"accession":"PF07589","entry_id":null,"type":"conserved_site","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR013424","hierarchy":null,"name":{"name":"PEP-CTERM protein-sorting motif","short":"PEP_exosort_dom"},"description":[{"text":"<p>This entry describes a 25-residue motif that includes an invariant Pro-Glu-Pro (PEP) motif, a thirteen-residue strongly hydrophobic sequence likely to span the membrane, and a five-residue strongly basic motif that often contains four Arg residues. In most cases, this motif is found within nine residues of the C-terminal end of the protein. Proteins containing this motif typically have signal sequences at the N-terminal [[cite:PUB00034422],[cite:PUB00105164]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00105164":{"PMID":29473278,"ISBN":null,"volume":"20","issue":"5","year":2018,"title":"Both widespread PEP-CTERM proteins and exopolysaccharides are required for floc formation of Zoogloea resiniphila and other activated sludge bacteria.","URL":null,"raw_pages":"1677-1692","medline_journal":"Environ Microbiol","ISO_journal":"Environ Microbiol","authors":["Gao N","Xia M","Dai J","Yu D","An W","Li S","Liu S","He P","Zhang L","Wu Z","Bi X","Chen S","Haft DH","Qiu D."],"DOI_URL":null},"PUB00034422":{"PMID":16930487,"ISBN":null,"volume":"4","issue":null,"year":2006,"title":"Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.","URL":null,"raw_pages":"29","medline_journal":"BMC Biol","ISO_journal":"BMC Biol.","authors":["Haft DH","Paulsen IT","Ward N","Selengut JD."],"DOI_URL":"http://dx.doi.org/10.1186/1741-7007-4-29"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":252,"interactions":0,"matches":18734,"pathways":0,"proteins":18700,"proteomes":1716,"sets":0,"structural_models":{"alphafold":12061},"structures":0,"taxa":3064},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":151,"alignment:full":12560},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}