This domain appears to be found only in a small family of Chlamydia species [[cite:PUB00097825]]. It is usually found repeated. This domain can be found in translocated actin-recruiting phosphoprotein (Tarp) from Chlamydia trachomatis serovar L2. Tarp appears to initiate or participate in signalling events that regulate the actin recruitment, which ultimately leads to internalisation [[cite:PUB00075564]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00075564":{"PMID":15199184,"ISBN":null,"volume":"101","issue":"27","year":2004,"title":"A chlamydial type III translocated protein is tyrosine-phosphorylated at the site of entry and associated with recruitment of actin.","URL":null,"raw_pages":"10166-71","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Clifton DR","Fields KA","Grieshaber SS","Dooley CA","Fischer ER","Mead DJ","Carabeo RA","Hackstadt T."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0402829101"},"PUB00097825":{"PMID":22506068,"ISBN":null,"volume":"7","issue":"4","year":2012,"title":"The Chlamydia psittaci genome: a comparative analysis of intracellular pathogens.","URL":null,"raw_pages":"e35097","medline_journal":"PLoS One","ISO_journal":"PLoS One","authors":["Voigt A","Schofl G","Saluz HP."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":235,"pathways":0,"proteins":105,"proteomes":17,"sets":0,"structural_models":{"alphafold":95},"structures":0,"taxa":38},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":3},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}