{"metadata":{"accession":"PF07571","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR011442","hierarchy":null,"name":{"name":"TAF6 C-terminal HEAT repeat domain","short":"TAF6_C"},"description":[{"text":"<p>TAF6_C is the C-terminal domain of the TAF6 subunit of the general transcription factor TFIID. The crystal structure reveals the presence of five conserved HEAT repeats. This region is necessary for the complexing together of the subunits TAF5, TAF6 and TAF9 [[cite:PUB00075536],[cite:PUB00099783],[cite:PUB00122818]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00122818":{"PMID":27007846,"ISBN":null,"volume":"531","issue":"7596","year":2016,"title":"Structure of promoter-bound TFIID and model of human pre-initiation complex assembly.","URL":null,"raw_pages":"604-9","medline_journal":"Nature","ISO_journal":"Nature","authors":["Louder RK","He Y","Lopez-Blanco JR","Fang J","Chacon P","Nogales E."],"DOI_URL":null},"PUB00099783":{"PMID":29485702,"ISBN":null,"volume":"285","issue":"8","year":2018,"title":"Mutational analysis of TAF6 revealed the essential requirement of the histone-fold domain and the HEAT repeat domain for transcriptional activation.","URL":null,"raw_pages":"1491-1510","medline_journal":"FEBS J","ISO_journal":"FEBS J","authors":["Dahiya R","Natarajan K."],"DOI_URL":null},"PUB00075536":{"PMID":22696218,"ISBN":null,"volume":"287","issue":"33","year":2012,"title":"TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.","URL":null,"raw_pages":"27580-92","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Scheer E","Delbac F","Tora L","Moras D","Romier C."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M112.379206"}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":97,"interactions":0,"matches":5386,"pathways":0,"proteins":5265,"proteomes":3077,"sets":1,"structural_models":{"alphafold":4442},"structures":43,"taxa":8172},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":102,"alignment:full":3992},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4atg","name":"TAF6 C-terminal domain from Antonospora locustae"}}}