This domain is found in several cell surface proteins, such as extracellular matrix-binding protein ebh [[cite:PUB00014728]]. Some members are involved in antibiotic resistance (e.g [swissprot:Q9RL69] and [swissprot:Q9LCJ9]) [[cite:PUB00014727]] and/or cellular adhesion (e.g. [swissprot:Q931R6]) [[cite:PUB00014728]]. In some proteins it is repeated more than fifteen times, being the most repeated domain in streptococci [[cite:PUB00097824]]. This is a predominantly alpha-helical domain that form a long, thin, fibre-like structure and it has been proposed to function as a stalk that helps the adhesive non-repeat region (NRR) of proteins protrude beyond the cell surface [[cite:PUB00097823],[cite:PUB00065268]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00097823":{"PMID":33465168,"ISBN":null,"volume":"17","issue":"1","year":2021,"title":"A novel sialic acid-binding adhesin present in multiple species contributes to the pathogenesis of Infective endocarditis.","URL":null,"raw_pages":"e1009222","medline_journal":"PLoS Pathog","ISO_journal":"PLoS Pathog","authors":["Gaytan MO","Singh AK","Woodiga SA","Patel SA","An SS","Vera-Ponce de Leon A","McGrath S","Miller AR","Bush JM","van der Linden M","Magrini V","Wilson RK","Kitten T","King SJ."],"DOI_URL":null},"PUB00097824":{"PMID":22921469,"ISBN":null,"volume":"100","issue":"6","year":2012,"title":"Protein domain repetition is enriched in Streptococcal cell-surface proteins.","URL":null,"raw_pages":"370-9","medline_journal":"Genomics","ISO_journal":"Genomics","authors":["Lin IH","Hsu MT","Chang CH."],"DOI_URL":null},"PUB00065268":{"PMID":22977243,"ISBN":null,"volume":"287","issue":"45","year":2012,"title":"The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an N-terminal domain containing a carbohydrate-binding module.","URL":null,"raw_pages":"38178-89","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Linke C","Siemens N","Oehmcke S","Radjainia M","Law RH","Whisstock JC","Baker EN","Kreikemeyer B."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M112.376434"},"PUB00014727":{"PMID":10332717,"ISBN":null,"volume":"5","issue":"1","year":1999,"title":"Mrp--a new auxiliary gene essential for optimal expression of methicillin resistance in Staphylococcus aureus.","URL":null,"raw_pages":"9-18","medline_journal":"Microb Drug Resist","ISO_journal":"Microb. Drug Resist.","authors":["Wu SW","De Lencastre H."],"DOI_URL":null},"PUB00014728":{"PMID":12438342,"ISBN":null,"volume":"70","issue":"12","year":2002,"title":"Analysis of Ebh, a 1.1-megadalton cell wall-associated fibronectin-binding protein of Staphylococcus aureus.","URL":null,"raw_pages":"6680-7","medline_journal":"Infect Immun","ISO_journal":"Infect. Immun.","authors":["Clarke SR","Harris LG","Richards RG","Foster SJ."],"DOI_URL":"http://dx.doi.org/10.1128/IAI.70.12.6680-6687.2002"}},"set_info":{"accession":"CL0598","name":"B_GA"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":192,"interactions":0,"matches":2712,"pathways":0,"proteins":393,"proteomes":153,"sets":1,"structural_models":{"alphafold":112},"structures":0,"taxa":310},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":89,"alignment:full":637},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}