This conserved domain of unknown function is usually found tandemly repeated in the nuclear receptor coactivator family (NCOA1/2/3, also known as the SRC/p160 nuclear receptor coactivator family, which are ligand-dependent transcription factors [[cite:PUB00097822],[cite:PUB00069373]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00069373":{"PMID":10713439,"ISBN":null,"volume":"245","issue":"1","year":2000,"title":"The SRC family of nuclear receptor coactivators.","URL":null,"raw_pages":"1-11","medline_journal":"Gene","ISO_journal":"Gene","authors":["Leo C","Chen JD."],"DOI_URL":"http://dx.doi.org/10.1016/S0378-1119(00)00024-X"},"PUB00097822":{"PMID":21854393,"ISBN":null,"volume":"119","issue":"3","year":2011,"title":"Steroid receptor coactivator 2 modulates steroid-dependent male sexual behavior and neuroplasticity in Japanese quail (Coturnix japonica).","URL":null,"raw_pages":"579-93","medline_journal":"J Neurochem","ISO_journal":"J Neurochem","authors":["Niessen NA","Balthazart J","Ball GF","Charlier TD."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":62,"interactions":0,"matches":3753,"pathways":0,"proteins":2780,"proteomes":701,"sets":0,"structural_models":{"alphafold":226},"structures":0,"taxa":2146},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":3131},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}