Members of this family of sugar isomerases belong to the cupin superfamily and consist of group I and II of D-lyxose isomerases [[cite:PUB00103833]]. The enzyme from Cohnella laevoribosii has been shown to be specific for D-lyxose, L-ribose, and D-mannose [[cite:PUB00075374]]. E. coli sugar isomerase (EcSI) shows a preference for D-lyxose and D-mannose [[cite:PUB00055252]] and its active site is highly similar to YdaE from the sigma B regulon of Bacillus subtilis [[cite:PUB00103833]].
","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075374":{"PMID":17189362,"ISBN":null,"volume":"189","issue":"5","year":2007,"title":"Characterization of a novel D-lyxose isomerase from Cohnella laevoribosii RI-39 sp. nov.","URL":null,"raw_pages":"1655-63","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Cho EA","Lee DW","Cha YH","Lee SJ","Jung HC","Pan JG","Pyun YR."],"DOI_URL":"http://dx.doi.org/10.1128/JB.01568-06"},"PUB00144158":{"PMID":21520290,"ISBN":null,"volume":"79","issue":"6","year":2011,"title":"The structure of a D-lyxose isomerase from the σB regulon of Bacillus subtilis.","URL":null,"raw_pages":"2015-9","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Marles-Wright J","Lewis RJ."],"DOI_URL":null},"PUB00103833":{"PMID":34422783,"ISBN":null,"volume":"9","issue":null,"year":2021,"title":"Biochemical and Structural Characterisation of a Novel D-Lyxose Isomerase From the Hyperthermophilic Archaeon Thermofilum sp.","URL":null,"raw_pages":"711487","medline_journal":"Front Bioeng Biotechnol","ISO_journal":"Front Bioeng Biotechnol","authors":["De Rose SA","Kuprat T","Isupov MN","Reinhardt A","Schonheit P","Littlechild JA."],"DOI_URL":null},"PUB00055252":{"PMID":20615418,"ISBN":null,"volume":"401","issue":"5","year":2010,"title":"Structure-based annotation of a novel sugar isomerase from the pathogenic E. coli O157:H7.","URL":null,"raw_pages":"866-81","medline_journal":"J Mol Biol","ISO_journal":"J. Mol. Biol.","authors":["van Staalduinen LM","Park CS","Yeom SJ","Adams-Cioaba MA","Oh DK","Jia Z."],"DOI_URL":"http://dx.doi.org/10.1016/j.jmb.2010.06.063"}},"set_info":{"accession":"CL0029","name":"Cupin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":1432,"pathways":0,"proteins":1432,"proteomes":1296,"sets":1,"structural_models":{"alphafold":919},"structures":3,"taxa":2278},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":179,"alignment:full":774},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3kmh","name":"Crystal Structure of a Novel Sugar Isomerase from E. coli O157:H7"}}}