{"metadata":{"accession":"PF07381","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010863","hierarchy":null,"name":{"name":"EarA-like","short":"EarA"},"description":[{"text":"<p>This family includes EarA from Methanococcus maripaludis (MMP1718, [swissprot:Q6LWJ1]) and similar sequences from archaea. EarA is a transcriptional activator that directly regulates the fla operon, which contains genes involved in archaella formation [[cite:PUB00158985],[cite:PUB00158986]]. Proteins in this family possess a winged helix DNA -binding domain.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00158985":{"PMID":27314758,"ISBN":null,"volume":"102","issue":"1","year":2016,"title":"Identification of the first transcriptional activator of an archaellum operon in a euryarchaeon.","URL":null,"raw_pages":"54-70","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Ding Y","Nash J","Berezuk A","Khursigara CM","Langelaan DN","Smith SP","Jarrell KF."],"DOI_URL":"https://doi.org/10.1111/mmi.13444"},"PUB00158987":{"PMID":28769898,"ISBN":null,"volume":"8","issue":null,"year":2017,"title":"Bypassing the Need for the Transcriptional Activator EarA through a Spontaneous Deletion in the BRE Portion of the <i>fla</i> Operon Promoter in <i>Methanococcus maripaludis</i>.","URL":null,"raw_pages":"1329","medline_journal":"Front Microbiol","ISO_journal":"Front Microbiol","authors":["Ding Y","Berezuk A","Khursigara CM","Jarrell KF."],"DOI_URL":"https://doi.org/10.3389/fmicb.2017.01329"},"PUB00158986":{"PMID":28535845,"ISBN":null,"volume":"163","issue":"5","year":2017,"title":"Phylogenetic distribution of the euryarchaeal archaellum regulator EarA and complementation of a <i>Methanococcus maripaludis ∆earA</i> mutant with heterologous <i>earA</i> homologues.","URL":null,"raw_pages":"804-815","medline_journal":"Microbiology (Reading)","ISO_journal":"Microbiology (Reading)","authors":["Ding Y","Berezuk A","Khursigara CM","Jarrell KF."],"DOI_URL":"https://doi.org/10.1099/mic.0.000464"}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":76,"pathways":0,"proteins":76,"proteomes":57,"sets":1,"structural_models":{"alphafold":75},"structures":0,"taxa":144},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":36},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}