{"metadata":{"accession":"PF07366","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009959","hierarchy":null,"name":{"name":"SnoaL-like polyketide cyclase","short":"SnoaL"},"description":[{"text":"<p>This family includes SnoaL [[cite:PUB00021066]] a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486.  The proteins in this family adopt a distorted alpha-beta barrel fold [[cite:PUB00021066]].  Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation [[cite:PUB00021066]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00021066":{"PMID":15071504,"ISBN":null,"volume":"23","issue":"9","year":2004,"title":"Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation.","URL":null,"raw_pages":"1911-21","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Sultana A","Kallio P","Jansson A","Wang JS","Niemi J","Mantsala P","Schneider G."],"DOI_URL":"http://dx.doi.org/10.1038/sj.emboj.7600201"}},"set_info":{"accession":"CL0051","name":"NTF2"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":124,"interactions":0,"matches":15446,"pathways":0,"proteins":14779,"proteomes":7283,"sets":1,"structural_models":{"alphafold":9298},"structures":19,"taxa":11082},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":29,"alignment:full":7771},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5x7l","name":"Structure of TsrD from Streptomyces laurentii"}}}