{"metadata":{"accession":"PF07326","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR009932","hierarchy":null,"name":{"name":"Regulator of chromosome segregation 1","short":"RCS1"},"description":[{"text":"<p>This family consists of several mammalian proteins of around 240 residues in length. Family members include regulator of chromosome segregation 1 (RCS1), also known as FAM64A, CATS or PIMREG (PICALM-interacting mitotic regulator). It is a substrate of APC/C. It may control the metaphase to anaphase transition [[cite:PUB00084339]]. It is also a substrate of the Kinase Interacting Stathmin (KIS). RCS1 is highly expressed in cancer cell lines in a cell cycle dependent manner and is induced by mitogens [[cite:PUB00084340]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00084340":{"PMID":23419774,"ISBN":null,"volume":"1833","issue":"5","year":2013,"title":"The CATS (FAM64A) protein is a substrate of the Kinase Interacting Stathmin (KIS).","URL":null,"raw_pages":"1269-79","medline_journal":"Biochim Biophys Acta","ISO_journal":"Biochim. Biophys. Acta","authors":["Archangelo LF","Greif PA","Maucuer A","Manceau V","Koneru N","Bigarella CL","Niemann F","dos Santos MT","Kobarg J","Bohlander SK","Saad ST."],"DOI_URL":"http://dx.doi.org/10.1016/j.bbamcr.2013.02.004"},"PUB00084339":{"PMID":18757745,"ISBN":null,"volume":"105","issue":"36","year":2008,"title":"RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.","URL":null,"raw_pages":"13415-20","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Zhao WM","Coppinger JA","Seki A","Cheng XL","Yates JR 3rd","Fang G."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0709227105"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":1238,"pathways":0,"proteins":1192,"proteomes":706,"sets":0,"structural_models":{"alphafold":1113},"structures":0,"taxa":2154},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":1090},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}