This family consists of uncharacterised bacterial proteins mainly found in Proteobacteria, including YcfL from Escherichia coli and Putative lipoprotein from Campylobacter jejuni. This protein adopts a single domain configuration with two beta-sheets formed respectively by three and four beta-strands (beta-sandwich) and contains a Greek key motif, representing a singular variant of the Ig-like fold. Many proteins of this group have a lipid attachment site at the N-terminal of this domain, which together with the structure solved, suggests a role in bacterial lipoproteins [[cite:PUB00100676]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00100676":{"PMID":22987763,"ISBN":null,"volume":"80","issue":"12","year":2012,"title":"Crystal structure of the Campylobacter jejuni Cj0090 protein reveals a novel variant of the immunoglobulin fold among bacterial lipoproteins.","URL":null,"raw_pages":"2804-9","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Paek S","Kawai F","Choi KJ","Yeo HJ."],"DOI_URL":null}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":5,"interactions":0,"matches":1348,"pathways":0,"proteins":1348,"proteomes":1336,"sets":1,"structural_models":{"alphafold":828},"structures":2,"taxa":1945},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":422},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4gio","name":"Crystal structure of Campylobacter jejuni cj0090"}}}