This family consists of several hypothetical Enterobacterial proteins of around 100 residues in length. Members of this family are often described as YbjC. In E. coli the ybjC gene is located downstream of nfsA (which encodes the major oxygen-insensitive nitroreductase). It is thought that nfsA and ybjC form an operon an its promoter is a class I SoxS-dependent promoter [[cite:PUB00013045]]. The function of this family is unknown.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00013045":{"PMID":11741843,"ISBN":null,"volume":"184","issue":"1","year":2002,"title":"Regulation of the nfsA Gene in Escherichia coli by SoxS.","URL":null,"raw_pages":"51-8","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Paterson ES","Boucher SE","Lambert IB."],"DOI_URL":"http://dx.doi.org/10.1128/JB.184.1.51-58.2002"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":331,"pathways":0,"proteins":331,"proteomes":330,"sets":0,"structural_models":{"alphafold":207},"structures":0,"taxa":522},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":93},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}