{"metadata":{"accession":"PF07190","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR010806","hierarchy":null,"name":{"name":"Tumour necrosis factor receptor, SECRET domain","short":"CrmD_SECRET"},"description":[{"text":"<p>This domain, named as the SECRET domain, is found at the C-terminal end of Tumour necrosis factor receptor (CrmD) from the orthopoxvirus Ectromelia virus. This domain binds a subset of human and mouse CC, CXC and C chemokines. It is thought to be responsible for the anti-chemokine activity of CrmD. The SECRET domain monomer adopts a beta-sandwich fold, consisting of two parallel beta-sheets with five and six anti-parallel strands, and the connecting loops [[cite:PUB00151577]]. This domain is also found in other uncharacterised sequences from poxvirus, including Protein OPG192 and Protein C8 from Vaccinia virus.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00151577":{"PMID":21829356,"ISBN":null,"volume":"7","issue":"7","year":2011,"title":"Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor.","URL":null,"raw_pages":"e1002162","medline_journal":"PLoS Pathog","ISO_journal":"PLoS Pathog","authors":["Xue X","Lu Q","Wei H","Wang D","Chen D","He G","Huang L","Wang H","Wang X."],"DOI_URL":null}},"set_info":{"accession":"CL0653","name":"VCCI"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":87,"pathways":0,"proteins":87,"proteomes":19,"sets":1,"structural_models":{"alphafold":51},"structures":2,"taxa":92},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":24},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3on9","name":"The SECRET domain from Ectromelia virus"}}}