{"metadata":{"accession":"PF07180","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR020357","hierarchy":null,"name":{"name":"CaiF/GrlA transcriptional regulator","short":"CaiF_GrlA"},"description":[{"text":"<p>This is a family of transcriptional regulators. CaiF is involved in carnitine metabolism [[cite:PUB00077941]]. GrlA is encoded within the LEE type III secretion system in the enteropathogenic E. coli O157:H [[cite:PUB00076312]]. GrlR interacts with GrlA at its Helix-Turn-Helix (HTH) motif, preventing GrlA from binding to its target promoter DNA.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00076312":{"PMID":24092262,"ISBN":null,"volume":"4","issue":null,"year":2013,"title":"Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes.","URL":null,"raw_pages":"2546","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Padavannil A","Jobichen C","Mills E","Velazquez-Campoy A","Li M","Leung KY","Mok YK","Rosenshine I","Sivaraman J."],"DOI_URL":"http://dx.doi.org/10.1038/ncomms3546"},"PUB00077941":{"PMID":8631699,"ISBN":null,"volume":"178","issue":"5","year":1996,"title":"Identification and characterization of the caiF gene encoding a potential transcriptional activator of carnitine metabolism in Escherichia coli.","URL":null,"raw_pages":"1248-57","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Eichler K","Buchet A","Lemke R","Kleber HP","Mandrand-Berthelot MA."],"DOI_URL":null}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":166,"pathways":0,"proteins":166,"proteomes":128,"sets":1,"structural_models":{"alphafold":119},"structures":1,"taxa":215},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":45},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}